Faculty Collaboration Database

Downregulation of Protein Inhibitor of Activated STAT (PIAS) 1 Is Possibly Involved in the Process of Allograft Rejection. Transplant Proc 2020;52(1):414-418

Date

12/25/2019

Pubmed ID

31870601

DOI

10.1016/j.transproceed.2019.10.006

Scopus ID

2-s2.0-85076845451 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

BACKGROUND: Protein inhibitors of activated STAT (PIAS) proteins are regarded as negative regulators of cytokine-signaling and potent immunosuppressive proteins. However, their role in the process of organ transplant rejection has not been elucidated.

METHODS: In the current study, we compared transcript levels of PIAS1 to 4 in the peripheral blood of renal transplant recipients who experienced transplant rejection with those having normal transplant functions. Expression of PIAS1 was significantly higher in nonrejected group compared with the rejected group among male recipients; however, differences were insignificant among female recipients. Expressions of other PIAS genes were not different between study groups. Significant pairwise correlations were found between expression levels of PIAS genes in all study subgroups. The current investigation highlights the role of PIAS1 downregulation in the evolution of graft rejection and potentiates this gene as a predictive marker for transplant fate.

Author List

Nafar M, Kalantari S, Samavat S, Omrani MD, Arsang-Jang S, Taheri M, Ghafouri-Fard S

Author

Shahram Arsang-Jang Postdoctoral Fellow in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Allografts
Down-Regulation
Female
Graft Rejection
Humans
Male
Middle Aged
Protein Inhibitors of Activated STAT
Small Ubiquitin-Related Modifier Proteins