Expression Analysis of BDNF, BACE1, and Their Natural Occurring Antisenses in Autistic Patients. J Mol Neurosci 2020 Feb;70(2):194-200
Date
11/25/2019Pubmed ID
31760580DOI
10.1007/s12031-019-01432-7Scopus ID
2-s2.0-85075366866 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Autism spectrum disorder (ASD) as a multifaceted neurological syndrome affects many aspects of neuropsychologic functions. Dysregulated expressions of several genes have been documented in ASD patients. The current project aimed at comparison of transcript levels of brain derived neurotrophic factor (BDNF), beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), and their natural occurring antisenses in the peripheral blood of ASD individuals (n = 50, male/female = 38/12, age (mean ± standard deviation (SD)): 6 ± 1.4, age range: 3-8) and matched healthy persons (n = 50, male/female = 37/13, age (mean ± SD): 6 ± 1.74, age range: 3-8). We demonstrated remarkable higher levels of these genes in ASD patients. BACE1 transcript levels were correlated with transcript levels of BACE1-AS in all study participants. However, BACE1 transcript levels were not correlated with participants' age. BACE1-AS and BDNF transcript levels were correlated with age in female participants. Significant correlations were detected between transcript levels of BDNF and those of other genes in all study groups. The current results render further indications for contribution of BDNF, BACE1, and their antisenses in the course of ASD and suggested expression levels of these transcripts as putative markers for this neurobehavioral disorder. Such results might be applied in clinical setting for diagnosis of complicated ASD cases.
Author List
Ghafouri-Fard S, Namvar A, Arsang-Jang S, Komaki A, Taheri MAuthor
Shahram Arsang-Jang Postdoctoral Fellow in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Amyloid Precursor Protein SecretasesAspartic Acid Endopeptidases
Autistic Disorder
Biomarkers
Blood Cells
Brain-Derived Neurotrophic Factor
Child
Female
Humans
Male
RNA, Antisense
RNA, Messenger
