Suppressor of cytokine signaling genes in renal transplant receivers: Association with transplant fate. Transpl Immunol 2019 Oct;56:101228
Date
08/10/2019Pubmed ID
31398463DOI
10.1016/j.trim.2019.101228Scopus ID
2-s2.0-85070258670 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Suppressor of cytokine signaling (SOCS) proteins have acknowledged roles in regulation of immune responses. Moreover, their role in the evolution of allograft rejection is being elucidated. In the current investigation, we measured transcript levels of SOCS1-4 in the peripheral blood of a group of renal transplant recipients including both rejected and non-rejected allografts. Expression analyses showed that relative expression of SOCS2 was significantly higher in transplant-rejected male patients compared to non-rejected group. However, such significant difference was not detected between female subjects. Expression of SOCS2 was significantly higher in T-cell-mediated rejection group compared with non-rejected individuals with creatinine rise (Relative expression difference [95% CrI] =6.74 [0.94, 12.65], P = 0.043). Conversely, SOCS4 expression was significantly lower in T-cell-mediated rejection group compared with non-rejected individuals with creatinine rise (Relative expression difference [95% CrI] = -0.35 [-0.63, -0.1], P = 0.008). Patterns of correlations between expression levels of SOCS genes were different in non-rejected group. The obtained results indicate the role SOCS genes in development of allograft rejection.
Author List
Nafar M, Kalantari S, Omrani MD, Samavat S, Arsang-Jang S, Taheri M, Ghafouri-Fard SAuthor
Shahram Arsang-Jang Postdoctoral Fellow in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultCreatinine
Female
Gene Expression Regulation
Graft Rejection
Graft Survival
Humans
Kidney
Kidney Transplantation
Male
Middle Aged
Sex Factors
Suppressor of Cytokine Signaling Proteins
T-Lymphocytes
Transplantation, Homologous
Young Adult