Faculty Collaboration Database

Down-regulation of ERMN expression in relapsing remitting multiple sclerosis. Metab Brain Dis 2019 Oct;34(5):1261-1266

Date

05/28/2019

Pubmed ID

31123898

DOI

10.1007/s11011-019-00429-w

Scopus ID

2-s2.0-85071610170 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

Multiple Sclerosis (MS) is a chronic inflammatory disease causing demyelination and neurodegeneration in the central nervous system (CNS). Although the exact etiology of MS is still unclear, both genetic and environmental elements are regarded as causative factors. Environmental factors can induce a cascade of events in immune system leading to neuronal death and nerve demyelination. This paper aims to compare the peripheral transcript levels of Ermin (ERMN) (a gene with putative role in cytoskeletal rearrangements during myelinogenesis) and Listerin E3 Ubiquitin Protein Ligase 1 (LTN1) (a gene with functions in regulating innate immune system) between relapsing-remitting MS (RR-MS) patients and healthy controls. The results showed a significant decrease in ERMN expression (p = 0.022); whereas, no significant difference was detected in LTN1 expression between two groups (p = 0.935). The reduction in ERMN expression in leukocytes could be the cause of demyelinating process in RR-MS patients. Current findings might also have practical importance in prognosis and targeted therapies.

Author List

Salek Esfahani B, Gharesouran J, Ghafouri-Fard S, Talebian S, Arsang-Jang S, Omrani MD, Taheri M, Rezazadeh M

Author

Shahram Arsang-Jang Postdoctoral Fellow in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Down-Regulation
Female
Humans
Leukocytes
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting
Myelin Proteins
Ubiquitin-Protein Ligases
Young Adult