Faculty Collaboration Database

Expression Profile of Selected MicroRNAs in the Peripheral Blood of Multiple Sclerosis Patients: a Multivariate Statistical Analysis with ROC Curve to Find New Biomarkers for Fingolimod. J Mol Neurosci 2019 May;68(1):153-161

Date

03/22/2019

Pubmed ID

30895441

DOI

10.1007/s12031-019-01294-z

Scopus ID

2-s2.0-85063165520 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

Multiple sclerosis (MS) as a chronic autoimmune disease of the central nervous system (CNS) has been associated with dysregulation of several genes including miRNAs. In the present study, we assessed transcript levels of seven miRNAs (miR-96-5p, miR-211-5p, miR-15a, miR-34a-5p, miR-204-5p, miR-501-5p, and miR-524-5p) in the peripheral blood of MS patients compared with healthy subjects in association with response to fingolimod treatment. Expression levels of miR-211-5p and miR-34a-5p were significantly decreased in MS patients compared with healthy subjects (P values of 0.002 and 0.47). While subgroup analysis showed downregulation of miR-211-5p in both fingolimod responders and non-responders, miR-34a-5p expression was only decreased in responders. Moreover, miR-204-5p was downregulated in non-responder male patients compared with male controls. The current study underscores the role of miRNAs in determination of response to fingolimod in MS patients.

Author List

Eftekharian MM, Komaki A, Mazdeh M, Arsang-Jang S, Taheri M, Ghafouri-Fard S

Author

Shahram Arsang-Jang Postdoctoral Fellow in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Biomarkers
Case-Control Studies
Female
Fingolimod Hydrochloride
Humans
Immunosuppressive Agents
Male
MicroRNAs
Middle Aged
Multiple Sclerosis
ROC Curve