Faculty Collaboration Database

Assessment of Protein Prenylation Pathway in Multiple Sclerosis Patients. J Mol Neurosci 2018 Apr;64(4):581-590

Date

03/27/2018

Pubmed ID

29574663

DOI

10.1007/s12031-018-1052-z

Scopus ID

2-s2.0-85044360541 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disorder with several genetic and environmental factors being implicated in its pathogenesis. Protein prenylation as one of the important posttranslational modifications of proteins has crucial role in immune system regulation. In the current case-control study, we compared expression of five genes coding for the different subunits of proteins implicated in protein prenylation in 50 Iranian MS patients with those of healthy subjects. No significant difference has been found in FNTA and PGGT1B expressions between cases and controls. Spearman correlation analysis between FNTA relative expression and disease duration showed significant correlation in male patients (r = - 0.671, P = 0.024) but not female patients (r = 0.253, P = 0.12). FNTB expression was significantly higher in MS patients compared with healthy subjects. Spearman correlation analysis between FNTB relative expression and disease duration showed significant correlation in male patients (r = -0.876, P = 0.004) but not female patients (r = 0.296, P = 0.06). RABGGTA was significantly upregulated in total MS patients, total male patients, female patients aged between 30 and 40 and male patients aged >40 compared with corresponding control groups. RABGGTB was significantly downregulated in total MS patients, total female patients, and female patients aged > 40 compared with corresponding control groups. Totally, we demonstrated dysregulation of protein prenylation pathway in MS patients compared with healthy subjects. Future studies are needed to find the clinical implication of this pathway in MS patients.

Author List

Taheri M, Ghafouri-Fard S, Sayad A, Arsang-Jang S, Mazdeh M, Toghi M, Omrani MD

Author

Shahram Arsang-Jang Postdoctoral Fellow in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adaptor Proteins, Signal Transducing
Adult
Alkyl and Aryl Transferases
Case-Control Studies
Farnesyltranstransferase
Female
Humans
Male
Multiple Sclerosis
Protein Prenylation