Expression analysis of cytokine coding genes in epileptic patients. Cytokine 2018 Oct;110:284-287
Date
02/06/2018Pubmed ID
29396051DOI
10.1016/j.cyto.2018.01.017Scopus ID
2-s2.0-85041196282 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Epilepsy is a chronic disorder in which immune dysregulation is shown to be involved. Imbalances in the cytokine levels both in serum and brain tissue have been demonstrated in epileptic patients. In the present study, we assessed mRNA expression of TNF-α, TGF-β, IFN-γ, CXCL8, IL-1β, IL-2, 1L-4, IL-6, IL-17 and CXCL8 in blood samples of 40 epileptic patients compared with age- and sex-matched healthy controls by means of quantitative real time PCR. The relative levels of CXCL8 transcripts were significantly higher in total epileptic patients compared with healthy subjects (P = .023). Relative mRNA expression of IFN-γ was significantly higher in female patients compared with female healthy subject (P = .048). In addition, significant correlations have been found between the mRNA levels of mentioned cytokines. Such imbalance between expression of pro-inflammatory and anti-inflammatory cytokines might be implicated in the pathogenesis of epilepsy.
Author List
Mazdeh M, Omrani MD, Sayad A, Komaki A, Arsang-Jang S, Taheri M, Ghafouri-Fard SAuthor
Shahram Arsang-Jang Postdoctoral Fellow in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultCase-Control Studies
Cytokines
Epilepsy
Female
Humans
Inflammation
Male
RNA, Messenger
Serum
