Considering the downregulation of Tpm1.6 and Tpm1.7 in squamous cell carcinoma of esophagus as a potent biomarker. Per Med 2018 Sep;15(5):361-370
Date
09/28/2018Pubmed ID
30259780DOI
10.2217/pme-2018-0015Scopus ID
2-s2.0-85054636936 (requires institutional sign-in at Scopus site) 1 CitationAbstract
AIM: Squamous cell carcinoma of esophagus (SCCE) is an aggressive disease with a poor prognosis. Tropomyosins attach to actin microfilaments, providing its stability. Nonmuscle cells express Tpm isoforms such as Tpm1.6 and Tpm1.7 which are involved in cytoskeleton functional properties regulation.
MATERIALS & METHODS: The expression of Tpm1.6 and Tpm1.7 was analyzed in SCCE tissues and its association with clinicopathological parameters and survival of patients was assessed.
RESULTS: Tpm1.6 and Tpm1.7, besides TPM1 mRNA decreased considerably in SCCE tissues relative to normal esophageal tissues (p < 0.001). TPM1 downregulation level was significantly associated with the degree of tumor differentiation (p = 0.017).
CONCLUSION: Tpm1.6 and Tpm1.7 suppression play a crucial role in esophagus tumorigenesis and could be associated with SCCE poor prognosis.
Author List
Zare M, Hadi F, Alivand MRAuthor
Mohammadreza Alivand DPhil Postdoctoral Fellow in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Biomarkers, Tumor
Down-Regulation
Esophageal Neoplasms
Esophagus
Female
Humans
Male
Middle Aged
Protein Isoforms
RNA, Messenger
Survival Analysis
Transcriptome
Tropomyosin
