Emerging use of nanoparticles in diagnosis and treatment of breast cancer. Lancet Oncol 2006 Aug;7(8):657-67
Date
08/05/2006Pubmed ID
16887483DOI
10.1016/S1470-2045(06)70793-8Scopus ID
2-s2.0-33746648133 (requires institutional sign-in at Scopus site) 475 CitationsAbstract
The biological application of nanoparticles is a rapidly developing area of nanotechnology that raises new possibilities in the diagnosis and treatment of human cancers. In cancer diagnostics, fluorescent nanoparticles can be used for multiplex simultaneous profiling of tumour biomarkers and for detection of multiple genes and matrix RNA with fluorescent in-situ hybridisation. In breast cancer, three crucial biomarkers can be detected and accurately quantified in single tumour sections by use of nanoparticles conjugated to antibodies. In the near future, the use of conjugated nanoparticles will allow at least ten cancer-related proteins to be detected on tiny tumour sections, providing a new method of analysing the proteome of an individual tumour. Supermagnetic nanoparticles have exciting possibilities as contrast agents for cancer detection in vivo, and for monitoring the response to treatment. Several chemotherapy agents are available as nanoparticle formulations, and have at least equivalent efficacy and fewer toxic effects compared with conventional formulations. Ultimately, the use of nanoparticles will allow simultaneous tumour targeting and drug delivery in a unique manner. In this review, we give an overview of the use of clinically applicable nanoparticles in oncology, with particular focus on the diagnosis and treatment of breast cancer.
Author List
Yezhelyev MV, Gao X, Xing Y, Al-Hajj A, Nie S, O'Regan RMAuthor
Yun Xing Biostatistician I in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntineoplastic Agents
Biomarkers, Tumor
Breast Neoplasms
Diagnostic Imaging
Drug Delivery Systems
Humans
In Situ Hybridization, Fluorescence
Liposomes
Nanostructures
