Faculty Collaboration Database

Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromas. Muscle Nerve 1998 Dec;21(12):1748-58

Date

12/08/1998

Pubmed ID

9843078

DOI

10.1002/(sici)1097-4598(199812)21:12<1748::aid-mus18>3.0.co;2-k

Scopus ID

2-s2.0-0031789084 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

Histochemical staining for carbonic anhydrase and cholinesterase (CE) activities was used to analyze sensory and motor axon regeneration, respectively, during neuroma formation in transected and tube-encapsulated peripheral nerves. Median-ulnar and sciatic nerves in the rodent model permitted testing whether a 4 cm greater distance of the motor neuron soma from axotomy site or intrinsic differences between motor and sensory neurons influenced regeneration and neuroma formation 10, 30, and 90 days later. Ventral root radiculotomy confirmed that CE-stained axons were 97% alpha motor axons. Distance significantly delayed axon regeneration. When distance was negligible, sensory axons grew out sooner than motor axons, but motor axons regenerated to a greater quantity. These results indicate regeneration differences between axon subtypes and suggest more extensive branching of motor axons within the neuroma. Thus, both distance from injury site to soma and inherent motor and sensory differences should be considered in peripheral nerve repair strategies.

Author List

Macias MY, Lehman CT, Sanger JR, Riley DA

Author

James R. Sanger MD Professor in the Plastic Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Axons
Carbonic Anhydrases
Cholinesterases
Male
Motor Neurons
Nerve Fibers, Myelinated
Nerve Regeneration
Neuroma
Neurons, Afferent
Peripheral Nerves
Peripheral Nervous System Neoplasms
Rats
Rats, Sprague-Dawley