Massive splenomegaly and Epstein-Barr virus-associated infectious mononucleosis in a patient with Gaucher disease. J Pediatr Hematol Oncol 1999;21(1):47-9
Date
02/25/1999Pubmed ID
10029812DOI
10.1097/00043426-199901000-00010Scopus ID
2-s2.0-0032995288 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
PURPOSE: Gaucher disease should be considered in the differential diagnosis of a patient with Epstein-Barr virus (EBV) infection who has unexplained or disproportionate splenomegaly.
PATIENTS AND METHODS: A previously asymptomatic adolescent with EBV-associated infectious mononucleosis and massive splenomegaly is described. He was found to have Gaucher disease on bone marrow biopsy, which was performed to exclude a hematologic malignancy. The diagnosis was confirmed by assay of beta-glucosidase enzyme activity.
RESULTS: Regression of splenomegaly and improving hematologic indices.
CONCLUSION: Patients with infectious mononucleosis and disproportionate organomegaly should be investigated to exclude a hematologic malignancy or an underlying storage disorder such as Gaucher disease.
Author List
Eapen M, Hostetter M, Neglia JPAuthor
Mary Eapen MBBS, DCh, MRCPI, MS Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentGaucher Disease
Herpesvirus 4, Human
Humans
Infectious Mononucleosis
Male
Splenomegaly
