Standardization of relative cerebral blood volume (rCBV) image maps for ease of both inter- and intrapatient comparisons. Magn Reson Med 2010 Sep;64(3):907-13
Date
09/02/2010Pubmed ID
20806381Pubmed Central ID
PMC4323176DOI
10.1002/mrm.22445Scopus ID
2-s2.0-77956382561 (requires institutional sign-in at Scopus site) 60 CitationsAbstract
Relative cerebral blood volume (rCBV) measured using dynamic susceptibility contrast MRI suffers from interpatient and interstudy variability for the same tissue type. Traditionally, when a more quantitative assessment of rCBV is required, as for comparison across studies and patients, the rCBV values are normalized to the rCBV in a reference region such as normal-appearing white matter. However, this technique of normalization is subjective and time consuming and introduces user-dependent variability. In this study, we demonstrate that a method called standardization, applied to rCBV maps, is an objective means of translating all rCBV values to a consistent scale. This approach reduces interpatient and interstudy variability for the same tissue type, thus enabling easy and accurate visual and quantitative comparison across studies. One caveat to this approach is that it is not appropriate for the evaluation of global changes in blood volume, since systematic differences are removed in the process of standardization.
Author List
Bedekar D, Jensen T, Schmainda KMAuthor
Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Algorithms
Blood Volume
Blood Volume Determination
Brain
Cerebrovascular Circulation
Female
Humans
Image Enhancement
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
