Faculty Collaboration Database

Small bowel transplantation in the rat with immediate restoration of intestinal continuity. Microsurgery 1990;11(4):300-2

Date

01/01/1990

Pubmed ID

2255251

DOI

10.1002/micr.1920110412

Scopus ID

2-s2.0-0025221117 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

Compared with other rat transplant models, small bowel transplantation (SBT) is associated with higher peritransplant morbidity and mortality. We describe a two-stage technique of SBT in the rat that minimizes perioperative complications and also allows immediate restoration of intestinal continuity. Inbred Lewis strain rats were used as donors and recipients. A one-stage technique was originally adopted whereby the distal 50% of the jejunoileum was transplanted followed by near-total resection of the native small intestine and restoration of intestinal continuity. Among 20 rats transplanted with this technique, only one survived longer than 30 days. With the two-stage technique, transplantation of the donor jejunoileum in continuity was performed, followed by native enterectomy 7 days later. With the two-stage technique 17 of 20 rats survived indefinitely (greater than 50 days). Other important technical modifications are described. In the hands of a skilled microvascular surgeon, the two-stage SBT technique results in consistently improved survival and minimal morbidity.

Author List

Moore GH, Roza AM, Johnson CP, Telford GL, Adams MB

Author

Christopher P. Johnson MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anastomosis, Surgical
Animals
Ileum
Intestine, Small
Jejunum
Male
Mesenteric Arteries
Mesenteric Veins
Microsurgery
Rats
Rats, Inbred Lew
Survival Rate
Time Factors