Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Colonization by Streptococcus penumoniae in human immunodeficiency virus-infected children. Pediatr Infect Dis J 2000 Jul;19(7):608-12

Date

08/05/2000

Pubmed ID

10917217

DOI

10.1097/00006454-200007000-00005

Scopus ID

2-s2.0-0033623980   29 Citations

Abstract

OBJECTIVE: Children with HIV infection are particularly susceptible to invasive pneumococcal disease, yet the effect of HIV infection and its medical management on colonization and resistance to antibiotics are poorly described. To provide a basis for medical practice, we determined the prevalence of nasopharyngeal colonization and antibiotic resistance of Streptococcus pneumoniae in children with HIV infection.

METHODS: Cross-sectional prevalence sample of children attending the pediatric HIV and pulmonary clinics to examine nasopharyngeal colonization with S. pneumoniae and antibiotic resistance to beta-lactams and trimethoprim-sulfamethoxazole (T/S). Subjects were matched by age and date of clinic visit.

RESULTS: The colonization rate with S. pneumoniae of HIV-infected and -indeterminate children was equal to that of controls (20% vs. 19%). HIV infection, CDC staging or receipt of oral antibiotic therapy did not affect colonization. Isolates from HIV-infected and -indeterminate children were less likely to be penicillin-resistant than those from controls (18% vs. 50%). There was no difference in pneumococcal resistance to T/S among isolates from subjects and controls, despite 72% T/S use in the HIV clinic.

CONCLUSION: Colonization with S. pneumoniae in HIV disease is no different from that of comparable children. The high incidence of pneumococcal disease and prophylaxis with T/S are not related to nasopharyngeal colonization. Antibiotic prophylaxis of HIV-infected children does not necessarily lead to increased resistance of S. pneumoniae.

Author List

Polack FP, Flayhart DC, Zahurak ML, Dick JD, Willoughby RE

Author

Rodney E. Willoughby MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

AIDS-Related Opportunistic Infections
Acquired Immunodeficiency Syndrome
Adolescent
Anti-Bacterial Agents
Anti-Infective Agents
Carrier State
Child
Child, Preschool
Cohort Studies
Cross-Sectional Studies
Drug Resistance, Microbial
Female
HIV Infections
Humans
Infant
Lactams
Male
Nasal Mucosa
Nasopharynx
Penicillins
Pneumococcal Infections
Prevalence
Streptococcus pneumoniae
Trimethoprim, Sulfamethoxazole Drug Combination