Spirooxindoles as Potential Pharmacophores. Mini Rev Med Chem 2017;17(16):1515-1536
Date
10/24/2017Pubmed ID
29056096DOI
10.2174/1389557516666160624125108Scopus ID
2-s2.0-85032151951 (requires institutional sign-in at Scopus site) 96 CitationsAbstract
OBJECTIVE: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.
BACKGROUND: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.
CONCLUSION: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.
Author List
Panda SS, Jones RA, Bachawala P, Mohapatra PPAuthor
Rachel Jones Lipinski PhD Research Scientist I in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBiological Products
Drug Discovery
Humans
Indoles
Spiro Compounds
