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Spirooxindoles as Potential Pharmacophores. Mini Rev Med Chem 2017;17(16):1515-1536

Date

10/24/2017

Pubmed ID

29056096

DOI

10.2174/1389557516666160624125108

Scopus ID

2-s2.0-85032151951 (requires institutional sign-in at Scopus site)   90 Citations

Abstract

OBJECTIVE: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.

BACKGROUND: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.

CONCLUSION: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.

Author List

Panda SS, Jones RA, Bachawala P, Mohapatra PP

Author

Rachel Jones Lipinski Research Scientist I in the Biochemistry department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Biological Products
Drug Discovery
Humans
Indoles
Spiro Compounds