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Association between Metabolic Components and Subclinical Atherosclerosis in Korean Adults. Korean J Fam Med 2012 Jul;33(4):229-36

Date

08/24/2012

Pubmed ID

22916325

Pubmed Central ID

PMC3418342

DOI

10.4082/kjfm.2012.33.4.229

Scopus ID

2-s2.0-84868116677 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

BACKGROUND: Many studies have attempted to develop relatively simple and easy noninvasive measurements of atherosclerosis (NIMA), and each NIMA assesses different atherosclerotic properties. We, therefore, investigated the association between metabolic syndrome (MetS) components and different NIMAs.

METHODS: This study included 1,132 Korean subjects over 20 years of age who had visited a Health Promotion Center in Korea. Carotid injury (increased carotid intima-media thickness or plaques) was evaluated by ultrasonography and arterial stiffness by brachial-ankle pulse wave velocity. The MetS components were assessed according to the Asian criteria of the American Heart Association/National Heart, Lung, and Blood Institute.

RESULTS: Both arterial stiffness and carotid injury gradually deteriorated with increase in the number of MetS components. Arterial stiffness and carotid injury were associated with different MetS components, each of which had varying impact. After adjustment for all possible confounders such as age, sex, and lifestyle, elevated blood pressure (BP) was found to have the strongest association with arterial stiffness, whereas central obesity, impaired fasting plasma glucose, and elevated BP had comparable connection with carotid atherosclerosis.

CONCLUSION: Individual MetS components were related with subclinical atherosclerosis in different ways. Elevated BP showed the strongest association with arterial stiffness, while central obesity, impaired fasting plasma glucose, and elevated BP showed good correlation with carotid atherosclerosis.

Author List

Hwang IC, Suh SY, Seo AR, Ahn HY, Yim E

Author

Eunji Yim MD Assistant Professor in the Neurology department at Medical College of Wisconsin