Vascular endothelial function and hypertension: insights and directions. Curr Hypertens Rep 2010 Dec;12(6):448-55
Date
09/22/2010Pubmed ID
20857237Pubmed Central ID
PMC2982873DOI
10.1007/s11906-010-0150-2Scopus ID
2-s2.0-78649905840 (requires institutional sign-in at Scopus site) 364 CitationsAbstract
Hypertension contributes significantly to worldwide cardiovascular morbidity and mortality. Hypertension appears to have a complex association with endothelial dysfunction, a phenotypical alteration of the vascular endothelium that precedes the development of adverse cardiovascular events and portends future cardiovascular risk. This review concentrates on recent findings with respect to the mechanisms of hypertension-associated endothelial dysfunction, the interrelationship between these two entities, and the relationship of the efficacy of antihypertensive therapies to improvements in vascular homeostasis beyond blood pressure reduction. Current evidence suggests that hypertension and endothelial dysfunction are integrally related with respect to pathophysiologic mechanisms. Future studies will need to identify the key connections between hypertension and endothelial dysfunction to allow novel interventions to be designed and promulgated.
Author List
Dharmashankar K, Widlansky MEAuthor
Michael E. Widlansky MD Center Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntihypertensive Agents
Blood Pressure
Clinical Trials as Topic
Diet, Sodium-Restricted
Endothelium, Vascular
Endothelium-Dependent Relaxing Factors
Humans
Hypertension
Hypolipidemic Agents
Mice
Models, Animal
Oxidative Stress
Rats
Reactive Oxygen Species
Risk Factors
