Medical College of Wisconsin
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Vascular endothelial function and hypertension: insights and directions. Curr Hypertens Rep 2010 Dec;12(6):448-55

Date

09/22/2010

Pubmed ID

20857237

Pubmed Central ID

PMC2982873

DOI

10.1007/s11906-010-0150-2

Scopus ID

2-s2.0-78649905840   214 Citations

Abstract

Hypertension contributes significantly to worldwide cardiovascular morbidity and mortality. Hypertension appears to have a complex association with endothelial dysfunction, a phenotypical alteration of the vascular endothelium that precedes the development of adverse cardiovascular events and portends future cardiovascular risk. This review concentrates on recent findings with respect to the mechanisms of hypertension-associated endothelial dysfunction, the interrelationship between these two entities, and the relationship of the efficacy of antihypertensive therapies to improvements in vascular homeostasis beyond blood pressure reduction. Current evidence suggests that hypertension and endothelial dysfunction are integrally related with respect to pathophysiologic mechanisms. Future studies will need to identify the key connections between hypertension and endothelial dysfunction to allow novel interventions to be designed and promulgated.

Author List

Dharmashankar K, Widlansky ME

Author

Michael E. Widlansky MD Associate Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Antihypertensive Agents
Blood Pressure
Clinical Trials as Topic
Diet, Sodium-Restricted
Endothelium, Vascular
Endothelium-Dependent Relaxing Factors
Humans
Hypertension
Hypolipidemic Agents
Mice
Models, Animal
Oxidative Stress
Rats
Reactive Oxygen Species
Risk Factors
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d