Faculty Collaboration Database

Modelling covariate adjusted mortality relative to a standard population. Stat Med 1999 Jun 30;18(12):1529-40

Date

07/09/1999

Pubmed ID

10398290

DOI

10.1002/(sici)1097-0258(19990630)18:12<1529::aid-sim137>3.0.co;2-j

Scopus ID

2-s2.0-0033618089 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

A study of long term survival of 1487 patients given an allogeneic bone marrow transplant for acute myelogenous leukaemia and 729 patients given a transplant for severe aplastic anaemia was conducted by the International Bone Marrow Transplant Registry. One aim of this study is to determine if the mortality rates of these patients return after some period of time to the same mortality rate as in the general population. To examine this question a model for the relative mortality of a bone marrow transplant patient relative to a matched individual in the general population is presented. This model allows for different relative mortality rates depending on the risk factors the patient may have. We discuss an estimation procedure for this model and construct a test that the mortality rate in the transplanted population is the same as in the reference population over a given time interval.

Author List

Andersen PK, Horowitz MM, Klein JP, Socie G, Stone JV, Zhang MJ

Authors

Mary M. Horowitz MD, MS Professor in the Medicine department at Medical College of Wisconsin
Mei-Jie Zhang PhD Professor in the Institute for Health and Equity department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Age Factors
Anemia, Aplastic
Bone Marrow Transplantation
Child
Europe
Female
Graft vs Host Disease
Humans
Japan
Leukemia, Myeloid, Acute
Male
Models, Biological
North America
Reference Values
Regression Analysis
Risk Factors