Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Complex segregation analyses of bone mineral density in Chinese. Ann Hum Genet 2004 Mar;68(Pt 2):154-64

Date

03/11/2004

Pubmed ID

15008794

DOI

10.1046/j.1529-8817.2003.00082.x

Abstract

China has the largest population in the world; approximately 7% of the total population suffers from primary osteoporosis. Osteoporosis is mainly characterized by low bone mineral density (BMD). In the present study, familial correlation and segregation analyses for spine and hip BMDs have been undertaken for the first time in a Chinese sample composed of 401 nuclear families with a total of 1260 individuals. The results indicate a major gene of additive inheritance for hip BMD, whereas there is no evidence of a major gene influencing spine BMD. Significant familial residual effects are found for both traits, and heritability estimates (+/-SE) for spine and hip BMDs are 0.807(0.099) and 0.897(0.101), respectively. Sex and age differences in genotype-specific average BMD are also observed. This study provides the first evidence quantifying the high degree of genetic determination of BMD variation in the Chinese.

Author List

Liu PY, Qin YJ, Zhou Q, Recker RR, Deng HW

Author

Pengyuan Liu PhD Adjunct Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Age Factors
Asian Continental Ancestry Group
Bone Density
Female
Gene Frequency
Genotype
Hip
Humans
Likelihood Functions
Male
Nuclear Family
Sex Factors
Spine
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d