Faculty Collaboration Database

Resolution and contrast in magnetic resonance electrical impedance tomography (MREIT) and its application to cancer imaging. Technol Cancer Res Treat 2004 Dec;3(6):599-609

Date

11/25/2004

Pubmed ID

15560718

DOI

10.1177/153303460400300610

Scopus ID

2-s2.0-11144291548 (requires institutional sign-in at Scopus site)   63 Citations

Abstract

It has been reported that the electrical impedance of malignancies could be 20-40 times lower than healthy tissues and benign formations. Therefore, in vivo impedance imaging of suspicious lesions may prove to be helpful in improving the sensitivity and specificity of detecting malignant tumors. Several systems have been developed to map the conductivity distribution inside a volume of tissue, however they suffer from poor spatial resolution because the measurements are taken only from surface electrodes. MRI based impedance imaging (MREIT) is a novel method, in which weak electrical currents are injected into the tissue and the resulting perturbations in the magnetic field are measured using MRI. This method has been shown to provide better resolution compared to previous techniques of impedance imaging because the measurements are taken from inside the object on a uniform grid. Thus, it has the potential to be a useful modality that may detect malignancies earlier. Several phantom imaging experiments were performed to investigate the spatial resolution and dynamic range of contrast of this technique. The method was also applied to a live rat bearing a R3230 AC tumor. Tumor location was identified by contrast enhanced imaging.

Author List

Muftuler LT, Hamamura M, Birgul O, Nalcioglu O

Author

Lutfi Tugan Muftuler PhD Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Brain Neoplasms
Electric Impedance
Endosonography
Magnetic Resonance Imaging
Rats