Faculty Collaboration Database

Altered metabolites in newborns with persistent pulmonary hypertension. Pediatr Res 2018 Aug;84(2):272-278

Date

06/14/2018

Pubmed ID

29895840

Pubmed Central ID

PMC7691760

DOI

10.1038/s41390-018-0023-y

Scopus ID

2-s2.0-85048355721 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

BACKGROUND: There is an emerging evidence that pulmonary hypertension is associated with amino acid, carnitine, and thyroid hormone aberrations. We aimed to characterize metabolic profiles measured by the newborn screen (NBS) in infants with persistent pulmonary hypertension of the newborn (PPHN) METHODS: Nested case-control study from population-based database. Cases were infants with ICD-9 code for PPHN receiving mechanical ventilation. Controls receiving mechanical ventilation were matched 2:1 for gestational age, sex, birth weight, parenteral nutrition administration, and age at NBS collection. Infants were divided into derivation and validation datasets. A multivariable logistic regression model was derived from candidate metabolites, and the area under the receiver operator characteristic curve (AUROC) was generated from the validation dataset.

RESULTS: We identified 1076 cases and 2152 controls. Four metabolites remained in the final model. Ornithine (OR 0.32, CI 0.26-0.41), tyrosine (OR 0.48, CI 0.40-0.58), and TSH 0.50 (0.45-0.55) were associated with decreased odds of PPHN; phenylalanine was associated with increased odds of PPHN (OR 4.74, CI 3.25-6.90). The AUROC was 0.772 (CI 0.737-0.807).

CONCLUSIONS: In a large, population-based dataset, infants with PPHN have distinct, early metabolic profiles. These data provide insight into the pathophysiology of PPHN, identifying potential therapeutic targets and novel biomarkers to assess the response.

Author List

Steurer MA, Oltman S, Baer RJ, Feuer S, Liang L, Paynter RA, Rand L, Ryckman KK, Keller RL, Jelliffe-Pawlowski LL

Author

Liang Liang PhD Assistant Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Area Under Curve
Birth Weight
Case-Control Studies
Female
Gestational Age
Humans
Infant, Newborn
Logistic Models
Male
Multivariate Analysis
Neonatal Screening
Ornithine
Persistent Fetal Circulation Syndrome
Phenylalanine
Respiration, Artificial
Thyrotropin
Treatment Outcome
Tyrosine