Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States. PLoS One 2015;10(7):e0133191
Date
07/22/2015Pubmed ID
26196858Pubmed Central ID
PMC4510282DOI
10.1371/journal.pone.0133191Scopus ID
2-s2.0-84941309531 (requires institutional sign-in at Scopus site) 34 CitationsAbstract
Both clinical and animal studies suggest that exercise may be an effective way to manage inflammatory and neuropathic pain conditions. However, existing animal studies commonly use forced exercise paradigms that incorporate varying degrees of stress, which itself can elicit analgesia, and thus may complicate the interpretation of the effects of exercise on pain. We investigated the analgesic potential of voluntary wheel running in the formalin model of acute inflammatory pain and the spared nerve injury model of neuropathic pain in mice. In uninjured, adult C57BL/6J mice, 1 to 4 weeks of exercise training did not alter nociceptive thresholds, lumbar dorsal root ganglia neuronal excitability, or hindpaw intraepidermal innervation. Further, exercise training failed to attenuate formalin-induced spontaneous pain. Lastly, 2 weeks of exercise training was ineffective in reversing spared nerve injury-induced mechanical hypersensitivity or in improving muscle wasting or hindpaw denervation. These findings indicate that in contrast to rodent forced exercise paradigms, short durations of voluntary wheel running do not improve pain-like symptoms in mouse models of acute inflammation and peripheral nerve injury.
Author List
Sheahan TD, Copits BA, Golden JP, Gereau RW 4thAuthor
Tayler D. Sheahan PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsExercise Therapy
Ganglia, Spinal
Inflammation
Mice
Mice, Inbred C57BL
Neuralgia
Pain Threshold
Peripheral Nerve Injuries
Physical Exertion
