PCPE2: Expression of multifunctional extracellular glycoprotein associated with diverse cellular functions. J Lipid Res 2024 Nov;65(11):100664
Date
10/08/2024Pubmed ID
39374805Pubmed Central ID
PMC11567036DOI
10.1016/j.jlr.2024.100664Scopus ID
2-s2.0-85209736611 (requires institutional sign-in at Scopus site)Abstract
Procollagen C-endopeptidase enhancer 2, known as PCPE2 or PCOC2 (gene name, PCOLCE2) is a glycoprotein that resides in the extracellular matrix, and is similar in domain organization to PCPE1/PCPE, PCOC1 (PCOLCE1/PCOLCE). Due to the many similarities between the two related proteins, PCPE2 has been assumed to have biological functions similar to PCPE. PCPE is a well-established enhancer of procollagen processing activating the enzyme, BMP-1. However, reports show that PCPE2 has a strikingly different tissue expression profile compared to PCPE. With that in mind and given the paucity of published studies on PCPE2, this review examines the current literature citing PCPE2 and its association with specific cell types and signaling pathways. Additionally, this review will present a brief history of PCPE2's discovery, highlighting structural and functional similarities and differences compared to PCPE. Considering the widespread use of RNA sequencing techniques to examine associations between cell-specific gene expression and disease states, we will show that PCPE2 is repeatedly found as a differentially regulated gene (DEG) significantly associated with a number of cellular processes, well beyond the scope of procollagen fibril processing.
Author List
Thomas MJ, Xu H, Wang A, Beg MA, Sorci-Thomas MGAuthor
Mary Sorci Thomas PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsExtracellular Matrix Proteins
Glycoproteins
Humans