Faculty Collaboration Database

Late outcomes after bone marrow transplant for aplastic anaemia. Br J Haematol 2000 Dec;111(3):754-60

Date

12/21/2000

Pubmed ID

11122134

DOI

10.1046/j.1365-2141.2000.02452.x

Scopus ID

2-s2.0-0034492317 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

Allogeneic transplantation is effective in reconstituting haemopoiesis in severe aplastic anaemia (SAA). We report long-term health-related outcomes in 37 children and young adults with SAA transplanted between 1975 and 1996. The median length of follow-up was 17 years (range, 4-25 years). Using a case-control design, late social and medical outcomes in transplant recipients were compared with 146 control subjects matched for gender and age. The majority of patients received an irradiation-containing preparative regimen. There were no significant differences in the self-rating of health status between transplant recipients and controls (P = 0.8), with 71% reporting their health status as excellent and 29% as good compared with 74% and 26% of controls. They demonstrate the same normal psychosexual function as their peers and have similar educational achievements and employment history. Transplant recipients and controls are equally likely to have held a job or be currently employed and there are no significant differences in their personal income (OR = 0.60, 95% CI = 0.11-3.37). Although transplant recipients have had problems related to health insurance policies, the majority have adequate health insurance coverage. There were no differences in chronic health problems between transplant recipients and control subjects, except for expected increases in cataracts, short stature in men, hypothyroidism and gonadal dysfunction. Using self-assessment, these transplant recipients indicated an excellent level of satisfaction and social integration, showing transplantation to be an effective long-term therapy for SAA.

Author List

Eapen M, Ramsay NK, Mertens AC, Robison LL, DeFor T, Davies SM

Author

Mary Eapen MBBS, DCh, MRCPI, MS Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Anemia, Aplastic
Bone Marrow Transplantation
Case-Control Studies
Child
Child, Preschool
Female
Fertility
Follow-Up Studies
Health Status
Humans
Infant
Insurance, Health
Logistic Models
Male
Marital Status
Social Adjustment
Survival Rate
Treatment Outcome