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Lacosamide as an Adjunctive Therapy in the Management of Refractory Neonatal Seizures: A Retrospective Study. J Child Neurol 2025 Apr;40(4):256-263

Date

12/05/2024

Pubmed ID

39636052

DOI

10.1177/08830738241299137

Scopus ID

2-s2.0-85211810947 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

ObjectiveNeonatal seizures present significant treatment challenges, often requiring adjunctive antiseizure medications. This study aimed to evaluate the efficacy of lacosamide as an adjunctive antiseizure medication in managing refractory neonatal seizures.MethodsThe study included neonates up to 44 weeks of corrected gestational age who received lacosamide treatment at a level 4 neonatal intensive care unit between January 2015 and December 2023. The collected data encompassed demographic features, birth history, perinatal/postnatal complications, seizure characteristics, and treatment details. The primary outcome was the response to lacosamide, assessed by changes in total seizure burden on electroencephalography (EEG). The cohort characteristics were compared between nonresponders and responders.ResultsThe final analysis was conducted on 18 neonates with available EEG data. Of all patients, 72% showed a favorable response to lacosamide treatment, as evidenced by a reduced seizure burden on EEG. The demographic and clinical characteristics of the neonates varied, including a range of seizure etiologies. Responder and nonresponder groups had no differences in clinical characteristics.ConclusionThis study suggests that lacosamide may be an effective adjunctive antiseizure medication in treating refractory neonatal seizures. Further prospective studies are warranted to confirm these findings and explore the long-term outcomes and safety profile of lacosamide in this vulnerable patient group.

Author List

Sah JP, Javarayee P, Jain S, Karia S, Karakas C

Author

Pradeep Javarayee MD Assistant Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Anticonvulsants
Electroencephalography
Female
Humans
Infant, Newborn
Male
Retrospective Studies
Seizures
Treatment Outcome