Medical College of Wisconsin
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Determination of drug-induced changes in functional MRI signal using a pharmacokinetic model. Hum Brain Mapp 1999;8(4):235-44



Pubmed ID


Pubmed Central ID




Scopus ID

2-s2.0-0032757698   69 Citations


As the applications of functional magnetic resonance imaging (fMRI) expand, there is a need for the development of new strategies for data extraction and analysis that do not require the presentation of stimuli in a repeated on/off pattern. A description and evaluation of a method and computer algorithm for the detection and analysis of brain activation patterns following acute drug administration using fMRI are presented. A waveform analysis protocol (WAP) input function has been developed that is based upon the single-dose pharmacokinetics of a drug of interest. As a result of this analysis, regional brain activation can be characterized by its localization and intensity of activation, onset of action, time to peak effect, and duration of action. A global statistical test for significant drug effects based upon the probability of a voxel being activated by a saline vehicle injection is applied to grouped data on a voxel by voxel basis. Representative data are presented using nicotine as a prototypical agent. Using this method, statistically significant drug-induced brain activation has been identified in several key cortical and subcortical brain regions.

Author List

Bloom AS, Hoffmann RG, Fuller SA, Pankiewicz J, Harsch HH, Stein EA


Harold H. Harsch MD Professor in the Psychiatry department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Computer Simulation
Image Processing, Computer-Assisted
Injections, Intravenous
Magnetic Resonance Imaging
Models, Neurological