Urine vascular biomarkers in Sturge-Weber syndrome. Vasc Med 2013 Jun;18(3):122-8
Date
05/31/2013Pubmed ID
23720035DOI
10.1177/1358863X13486312Scopus ID
2-s2.0-84878354318 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Sturge-Weber syndrome (SWS) consists of a capillary-venous vascular malformation of the brain, skin and eye. Urine vascular biomarkers have been demonstrated to be abnormal in other vascular anomalies and to correlate with clinical severity and progression. The current study investigated the use of urinary matrix metalloproteinase (MMP)-2, MMP-9, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) levels to non-invasively monitor the progression of SWS. Fifty-four urine samples were collected from patients seen at the Hunter Nelson Sturge-Weber Center at Kennedy Krieger Institute. Urine was analyzed for MMP-2, MMP-9, VEGF and bFGF levels and correlated with clinical outcome at the time of urine collection (n = 48) and 1 year following urine collection (n = 22). Analysis revealed that MMP-2 (p = 0.033) and MMP-9 (p = 0.010) were significantly more likely to be present in the urine of SWS subjects compared to controls and that bFGF was significantly more likely to be present at abnormal levels (p = 0.005). MMP-2 correlated with a more severe clinical score at the time of urine collection, while both MMP-2 and MMP-9 levels correlated with greater disease severity at time of collection. bFGF levels correlated with improved clinical score 1 year after urine collection. These results suggest that MMP-2 and MMP-9 levels may be useful in assessing SWS progression, as well as indicating which patients might benefit from more aggressive treatment, while bFGF levels may be useful in judging the efficacy of neurologic treatment in SWS.
Author List
Sreenivasan AK, Bachur CD, Lanier KE, Curatolo AS, Connors SM, Moses MA, Comi AMAuthor
Catherine Bachur MD, MA Maternal Fetal Medicine Fellow in the Obstetrics and Gynecology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Biomarkers, Tumor
Child
Child, Preschool
Female
Fibroblast Growth Factor 2
Humans
Infant
Male
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Risk Assessment
Sturge-Weber Syndrome
Vascular Endothelial Growth Factor A
Young Adult