Expanding clinical laboratory tobacco product evaluation methods to loose-leaf tobacco vaporizers. Drug Alcohol Depend 2016 Dec 01;169:33-40
Date
10/22/2016Pubmed ID
27768968Pubmed Central ID
PMC5140724DOI
10.1016/j.drugalcdep.2016.10.005Scopus ID
2-s2.0-84992128525 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
BACKGROUND: Novel tobacco products entering the US market include electronic cigarettes (ECIGs) and products advertised to "heat, not burn" tobacco. There is a growing literature regarding the acute effects of ECIGs. Less is known about "heat, not burn" products. This study's purpose was to expand existing clinical laboratory methods to examine, in cigarette smokers, the acute effects of a "heat, not burn" "loose-leaf tobacco vaporizer" (LLTV).
METHODS: Plasma nicotine and breath carbon monoxide (CO) concentration and tobacco abstinence symptom severity were measured before and after two 10-puff (30-s interpuff interval) product use bouts separated by 60min. LLTV effects were compared to participants' own brand (OB) cigarettes and an ECIG (3.3V; 1.5ohm; 18mg/ml nicotine).
RESULTS: Relative to OB, LLTV increased plasma nicotine concentration to a lesser degree, did not increase CO, and did not appear to reduce abstinence symptoms as effectively. Relative to ECIG, LLTV nicotine and CO delivery and abstinence symptom suppression did not differ. Participants reported that both the LLTV and ECIG were significantly less satisfying than OB.
CONCLUSIONS: Results demonstrate that LLTVs are capable of delivering nicotine and suppressing tobacco abstinence symptoms partially; acute effects of these products can be evaluated using existing clinical laboratory methods. Results can inform tobacco product regulation and may be predictive of the extent that these products have the potential to benefit or harm overall public health.
Author List
Lopez AA, Hiler M, Maloney S, Eissenberg T, Breland ABAuthor
Alexa Anderson PhD Associate Professor in the Nursing department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Carbon Monoxide
Electronic Nicotine Delivery Systems
Female
Humans
Laboratories
Male
Middle Aged
Nebulizers and Vaporizers
Nicotine
Public Health
Smoking
Substance Withdrawal Syndrome
Tobacco Products
Tobacco Use Disorder
Vaping
Young Adult
