Independent component analysis of normal and abnormal rhythm in twin pregnancies. Physiol Meas 2011 Jan;32(1):51-64
Date
11/26/2010Pubmed ID
21098910Pubmed Central ID
PMC3003612DOI
10.1088/0967-3334/32/1/004Scopus ID
2-s2.0-79551485957 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
We investigated the utility of ICA for evaluation of fetal rhythm in five uncomplicated twin pregnancies and in five twin pregnancies complicated by fetal arrhythmia. Using objective and subjective criteria, we sought to determine how the signal-to-noise ratio, signal fidelity and interference rejection are affected when synthesizing the fetal signal using all the signal-containing ICA components (rank-p ICA) versus using the single dominant component (rank-1 ICA). The signal of each fetus was most commonly distributed over 1 or 2 ICA components, as previously observed in studies of singleton pregnancies; however, in 8 of 26 (31%) cases the signal of each fetus was distributed over 3, 4 or even 5 ICA components. Rank-1 ICA provided the highest SNR and interference rejection, but at the cost of reduced signal fidelity. Our results corroborate that in twin pregnancies, including twin pregnancies complicated by fetal arrhythmia, rank-1 ICA is very effective in isolating the QRS complexes of each fetus; however, it has some limitations when used for fetal rhythm evaluation due to signal distortion. Occasionally, rank-1 ICA completely separates the P-wave and the T-wave from the QRS complex, thus requiring the mixing of several ICA components to achieve acceptable signal fidelity.
Author List
Mensah-Brown NA, Lutter WJ, Comani S, Strasburger JF, Wakai RTAuthor
Janette F. Strasburger MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
EchocardiographyFemale
Heart Rate, Fetal
Humans
Pregnancy
Pregnancy, Multiple
Twins
Ultrasonography, Prenatal
