Faculty Collaboration Database

Dual-center retrospective cohort analysis of high-risk cutaneous squamous cell carcinoma tumors. Arch Dermatol Res 2025 Jan 20;317(1):300

Date

01/21/2025

Pubmed ID

39833534

DOI

10.1007/s00403-024-03712-8

Scopus ID

2-s2.0-85216438984 (requires institutional sign-in at Scopus site)

Abstract

High-risk cutaneous squamous cell carcinoma (hr-cSCC) tumors exhibit aggressive behavior, leading to local recurrence, metastasis, and mortality. The management of hr-cSCC tumors is not well-defined. To clarify the impact of clinical risk factors and management strategies on disease-related outcomes (DROs) in patients with hr-cSCCs. This dual-center retrospective cohort study reviewed patient records from 2007 to 2023, focusing on hr-cSCC tumors classified as high-risk according to two staging systems. 160 adult patients with hr-cSCC were included. Tumors > 2 cm were associated with a higher risk of recurrence, metastasis, and mortality, with greater risk for tumors > 4 cm. Nonsurgical therapies were linked to higher recurrence and mortality rates compared to surgical monotherapy. Patients whose initial treatment was delayed > 60 days following biopsy had increased incidence of DROs. Other variables associated with at least one DRO included female sex, higher tumor grade, lymphovascular invasion, and advanced AJCC-8 stages. Limitations of this study include its retrospective design, narrow demographics, and variable follow-up times. This study identifies increased tumor diameter, non-surgical treatments, delayed treatment > 60 days after biopsy, female sex, tumor grade, lymphovascular invasion, and advanced tumor stage as significant risk factors for DROs in hr-cSCC. Importantly, our study provides new clarifying evidence that delayed surgical treatment of hr-cSCCs > 60 days after biopsy is associated with elevated incidence of DROs.

Author List

Calley B, Trieglaff K, Boswell N, Vu A, Popatia S, Rivera DB, Tsafack UK, Banerjee A, Vaughn OA, Clark MA

Authors

Olushola L. Akinshemoyin Vaughn MD Associate Professor in the Dermatology department at Medical College of Wisconsin
Anjishnu Banerjee PhD Associate Professor in the Data Science Institute department at Medical College of Wisconsin
Nicole Boswell MD Postdoctoral Researcher 1 in the Dermatology department at Medical College of Wisconsin
Melanie A. Clark MD Associate Professor in the Dermatology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Biopsy
Carcinoma, Squamous Cell
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Retrospective Studies
Risk Factors
Skin Neoplasms
Time-to-Treatment