Faculty Collaboration Database

Renin response to hemorrhage in conscious rats: effect of acute reductions in hematocrit. Am J Physiol 1990 Feb;258(2 Pt 2):R487-91

Date

02/01/1990

Pubmed ID

2178451

DOI

10.1152/ajpregu.1990.258.2.R487

Scopus ID

2-s2.0-0025329688 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

This study examined the effect of prior exchange transfusion and acute reduction in hematocrit on the subsequent plasma renin concentration (PRC) response to 15 ml/kg hemorrhage in conscious cannulated rats. Long-Evans rats (400-500 g) were assigned to one of eight groups (6-8 rats/group). Rats were exchanged transfused (5 ml total) with whole blood, red blood cells and saline, plasma, or isotonic saline, with the two latter groups showing a decrease in hematocrit of 10-20%. Thirty minutes after exchange transfusion, rats were either subjected to a 0- (control) or 15-ml/kg hemorrhage. Control rats showed no change in mean arterial pressure or PRC regardless of exchange transfusion. The rats exchange transfused with saline had a significant decrease in arterial pH and a more profound hypotension after hemorrhage. PRC ranged from 7 +/- 1 to 11 +/- 1 ng.ml-1.h-1 after exchange transfusion. Subsequent hemorrhage resulted in an increase in PRC that was significantly greater in the saline-transfused group (45 +/- 16 ng.ml-1.h-1) 10 min after hemorrhage. We conclude that exchange transfusion with saline leads to an augmented renin response to hemorrhage in part due to a decrease in arterial pH and more severe hypotension.

Author List

Raff H

Author

Hershel Raff PhD Professor in the Academic Affairs department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Exchange Transfusion, Whole Blood
Hematocrit
Hemorrhage
Hydrogen-Ion Concentration
Male
Rats
Rats, Inbred Strains
Renin