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Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities. Br J Haematol 2002 Jan;116(1):113-21

Date

02/14/2002

Pubmed ID

11841403

DOI

10.1046/j.1365-2141.2002.03193.x

Abstract

Cytogenetic findings in a few primary effusion lymphoma (PEL) cell lines have been reported, but only three complete karyotypes of primary specimens from patients with this neoplasm have been published. In this study, cytogenetic analysis was performed on 11 effusion specimens from 10 patients with PEL. We corroborate data obtained from the cell line studies that trisomy 7, trisomy 12 and aberrations in the proximal long arm of chromosome 1 (1q) are recurring cytogenetic aberrations in PEL and also identify breakpoints at 3q23, 7p22, 7q22, 10q24, 12q24, 13q22, 14q24, 14q32, 15p11.2 and Xq22 as well as +8, +15, +19, +X and -Y as recurring chromosome abnormalities. The identification of recurring cytogenetic aberrations may lead to delineation of the genetic events in PEL.

Author List

Wilson KS, McKenna RW, Kroft SH, Dawson DB, Ansari Q, Schneider NR

Author

Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Antigens, CD
Ascitic Fluid
Biomarkers
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 7
Genotype
Herpesvirus 8, Human
Humans
Immunophenotyping
Karyotyping
Lymphoma, AIDS-Related
Lymphoma, B-Cell
Male
Middle Aged
Trisomy