Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities. Br J Haematol 2002 Jan;116(1):113-21
Date
02/14/2002Pubmed ID
11841403DOI
10.1046/j.1365-2141.2002.03193.xScopus ID
2-s2.0-0036159706 (requires institutional sign-in at Scopus site) 41 CitationsAbstract
Cytogenetic findings in a few primary effusion lymphoma (PEL) cell lines have been reported, but only three complete karyotypes of primary specimens from patients with this neoplasm have been published. In this study, cytogenetic analysis was performed on 11 effusion specimens from 10 patients with PEL. We corroborate data obtained from the cell line studies that trisomy 7, trisomy 12 and aberrations in the proximal long arm of chromosome 1 (1q) are recurring cytogenetic aberrations in PEL and also identify breakpoints at 3q23, 7p22, 7q22, 10q24, 12q24, 13q22, 14q24, 14q32, 15p11.2 and Xq22 as well as +8, +15, +19, +X and -Y as recurring chromosome abnormalities. The identification of recurring cytogenetic aberrations may lead to delineation of the genetic events in PEL.
Author List
Wilson KS, McKenna RW, Kroft SH, Dawson DB, Ansari Q, Schneider NRAuthor
Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAntigens, CD
Ascitic Fluid
Biomarkers
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 7
Genotype
Herpesvirus 8, Human
Humans
Immunophenotyping
Karyotyping
Lymphoma, AIDS-Related
Lymphoma, B-Cell
Male
Middle Aged
Trisomy
