Depiction of intracranial vessels with MRA: utility of magnetization transfer saturation and gadolinium. J Comput Assist Tomogr 1999;23(4):597-602
Date
08/05/1999Pubmed ID
10433293DOI
10.1097/00004728-199907000-00021Scopus ID
2-s2.0-0032773322 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
PURPOSE: The purpose of this work was to quantitate the individual and combined effects of magnetization transfer (MT) saturation and gadolinium (Gd) on the visualization of intracranial vessels with MR angiography (MRA).
METHOD: Thirty-five subjects underwent two three-dimensional time-of-flight MRA sequences without and with MT and/or Gd. There were 14 MR angiograms without Gd or MT, 18 with MT only, 17 with Gd only, and 21 with both Gd and MT. On a projection image, a region of interest was drawn to delineate the arteries in the middle cerebral artery territory. The total area of blood vessels in the region of interest was calculated for each MR angiogram. Mean vessel areas for the four types of MRA were compared with analysis of variance.
RESULTS: MRA with either MT or Gd alone showed significantly more vessel area than MRA without either (p < 0.05). MRA with MT alone and MRA with Gd alone were not different from each other (p = 0.29). The improvement in vessel area measured by using MT and Gd together was significantly more than expected from the cumulative improvement of adding each alone (p < 0.05).
CONCLUSION: Combining MT and Gd synergistically improved the visualization of intracranial vessels on MRA.
Author List
Mathews VP, Ulmer JL, White ML, Hamilton CA, Reboussen DM, Elster ADAuthor
Vincent Mathews MD Chair, Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultCerebral Arteries
Cerebrovascular Disorders
Contrast Media
Female
Gadolinium
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Angiography
Male
