The Drake Health Registry Study: findings from fifteen years of continuous bladder cancer screening. Am J Ind Med 2003 Feb;43(2):142-8
Date
01/24/2003Pubmed ID
12541268DOI
10.1002/ajim.10166Scopus ID
2-s2.0-0037312823 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
BACKGROUND: The Drake Health Registry Study (DHRS) is an ongoing bladder cancer screening program initiated in 1986 due to workers' probable past exposure to the bladder carcinogen, beta-naphthylamine (BNA).
METHODS: At periodic screening visits, a health survey is administered and three screening tests are applied to a urine sample, urinalysis (UA), papanicolaou (PAP), and quantitative fluorescence image analysis (QFIA). Positive screens are eligible for a free bladder cystoscopy with random biopsies.
RESULTS: Forty of 51 persons eligible for diagnostic evaluation underwent cystoscopy. One person was diagnosed with carcinoma in situ, two with transitional cell papilloma, 14 with dysplasia, two of which developed transitional cell carcinoma; 26 had bladder abnormalities such as chronic inflammation, chronic cystitis, atypical changes, atypia, hyperplasia, or papillary clusters.
CONCLUSIONS: The DHRS continues to identify early stage bladder cancer and other abnormalities among workers exposed to BNA before 1981 and generates useful clinical, psycho-social, and epidemiologic data.
Author List
Marsh GM, Cassidy LDAuthor
Laura Cassidy PhD Associate Dean, Professor in the Institute for Health and Equity department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
2-NaphthylamineCarcinogens
Clinical Protocols
Cohort Studies
Female
Humans
Male
Mass Screening
Middle Aged
Occupational Diseases
Occupational Exposure
Pennsylvania
Registries
Risk Factors
Sensitivity and Specificity
Surveys and Questionnaires
Urinary Bladder Neoplasms
