CD36 in atherosclerosis. The role of a class B macrophage scavenger receptor. Ann N Y Acad Sci 2000 May;902:128-31; discussion 131-3
Date
06/24/2000Pubmed ID
10865832Scopus ID
2-s2.0-0034081958 (requires institutional sign-in at Scopus site) 67 CitationsAbstract
CD36, an 88 kD transmembrane glycoprotein, is an important receptor for oxidized lipoproteins. Unlike the LDL receptor, expression of CD36 is upregulated by this pro-atherogenic particle, and binding and uptake perpetuates a cycle of lipid accumulation and receptor expression. This effect is, in part, mediated by the transcription factor, peroxisome proliferator activated receptor-gamma (PPAR gamma), and its ligands. We have found that specific inhibitors of protein kinase C (PKC) reduce basal mRNA expression of CD36 and block induction of CD36 mRNA and protein by oxidized LDL (OxLDL) and a PPAR gamma ligand. In addition, PKC inhibitors block both PPAR gamma mRNA and protein expression. These results suggest that activation of CD36 gene expression by OxLDL involves activation and translocation of PKC with subsequent PPAR gamma activation. More recently, we have generated a mouse null for CD36, and crossed it with the atherogenic Apo E null strain. Evaluation of lesion development in these animals will allow us to assess the in vivo contribution of CD36 to the pathogenesis of atherosclerosis.
Author List
Nicholson AC, Febbraio M, Han J, Silverstein RL, Hajjar DPAuthor
Roy L. Silverstein MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsApolipoproteins E
Arteriosclerosis
CD36 Antigens
Gene Expression Regulation
Humans
Membrane Proteins
Mice
Mice, Knockout
Receptors, Cytoplasmic and Nuclear
Receptors, Immunologic
Receptors, Lipoprotein
Receptors, Scavenger
Scavenger Receptors, Class B
Transcription Factors
