Faculty Collaboration Database

Zolmitriptan induced acute coronary syndrome: a unique case. Am J Ther 2011 Sep;18(5):e153-6

Date

08/27/2011

Pubmed ID

21869671

DOI

10.1097/MJT.0b013e3182258e2e

Scopus ID

2-s2.0-80052700217 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

Triptans have been used for the acute treatment of migraine headaches for many years. Although their use can lead to coronary vasospasm, there are very few reports of triptans actually leading to myocardial infarction in patients with normal coronaries. We hereby present a 58-year-old man who presented to the emergency room with chest pain. Electrocardiogram demonstrated ST segment depression in the inferior leads with diffuse spasm of the distal right coronary artery seen on angiography, which was easily reversed by intracoronary nitroglycerine. We believe this is the first reported case of a patient with a myocardial infarction after taking oral zolmitriptan in which coronary angiogram clearly demonstrated coronary vasospasm reversal after intracoronary nitroglycerine. A detailed search of the literature for reported cases of myocardial infarction after triptan use is also provided.

Author List

Smith M, Golwala H, Lozano P

Author

Pedro Lozano MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acute Coronary Syndrome
Chest Pain
Electrocardiography
Humans
Male
Middle Aged
Migraine Disorders
Myocardial Infarction
Nitroglycerin
Oxazolidinones
Serotonin 5-HT1 Receptor Agonists
Tryptamines
Vasodilator Agents