Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. J Exp Med 1986 Jun 01;163(6):1595-600
Date
06/01/1986Pubmed ID
3086483Pubmed Central ID
PMC2188126DOI
10.1084/jem.163.6.1595Scopus ID
2-s2.0-0022517446 (requires institutional sign-in at Scopus site) 252 CitationsAbstract
Human endothelial cells activated with IL-1 express a surface membrane-oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury.
Author List
Nachman RL, Hajjar KA, Silverstein RL, Dinarello CAAuthor
Roy L. Silverstein MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Cells, CulturedEndothelium
Feedback
Glycoproteins
Humans
Infant, Newborn
Interleukin-1
Plasminogen Activators
Plasminogen Inactivators
Recombinant Proteins
Tissue Plasminogen Activator
Umbilical Veins
Urokinase-Type Plasminogen Activator
