Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1-seronegative hemophiliacs. J Infect Dis 1995 Jul;172(1):228-31
Date
07/01/1995Pubmed ID
7797917DOI
10.1093/infdis/172.1.228Scopus ID
2-s2.0-0029033896 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Blood samples were obtained from 16 hemophiliacs who had a 50%-94% defined risk of human immunodeficiency virus (HIV) type 1 infection on the basis of treatment history and from 14 controls not at risk for HIV infection. HIV-1 was not detected in any of 12 patient samples by cocultivation nor in 14 patient samples by the polymerase chain reaction. Peripheral blood cells from 7 seronegative hemophiliacs at highest risk of seroconversion (94%) were less susceptible to HIV-1 infection in vitro than were cells from healthy controls (P < .025, one-tailed Wilcoxon rank sum test). In contrast, the susceptibility to HIV-1 infection of lymphocytes from 6 seronegative hemophiliacs at moderate risk (50%-56%) of seroconversion did not differ from that of cells from controls or from high-risk hemophiliacs. Therefore, prolonged periods of seronegative HIV-1 infection are not common in this high-risk population. In addition, among hemophiliacs there may exist heterogeneity in susceptibility to HIV-1 infection in vitro and in vivo.
Author List
Lederman MM, Jackson JB, Kroner BL, White GC 3rd, Eyster ME, Aledort LM, Hilgartner MW, Kessler CM, Cohen AR, Kiger KPAuthor
Gilbert C. White MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultCD4 Lymphocyte Count
CD8-Positive T-Lymphocytes
Disease Susceptibility
Factor IX
Factor VIII
HIV Infections
HIV Seronegativity
HIV Seropositivity
HIV-1
Hemophilia A
Humans
Lymphocyte Count
Male
Polymerase Chain Reaction
Risk Factors
