Faculty Collaboration Database

Low incidence of thrombocytopenia with porcine mucosal heparin. A prospective multicenter study. Arch Intern Med 1989 Jun;149(6):1285-8

Date

06/01/1989

Pubmed ID

2658898

Scopus ID

2-s2.0-0024329913 (requires institutional sign-in at Scopus site)   30 Citations

Abstract

We treated 193 patients either intravenously (94) or subcutaneously (99) for at least 5 days with porcine intestinal mucosal heparin and followed them up prospectively with frequent platelet counts to determine the incidence of heparin-related thrombocytopenia and arterial thrombosis. None of the patients in the study developed severe thrombocytopenia (platelet count, less than 100 x 10(9)/L) or arterial thrombosis. Eight patients had a platelet count of 100 to 140 X 10(9)/L on one occasion, with a count of greater than 140 x 10(9)/L on the subsequent measurement. The mean (+/- SD) values of the initial and lowest platelet counts during therapy in all patients were 288 +/- 100 x 10(9)/L and 253 +/- 88 x 10(9)/L, respectively, with the lowest counts occurring on day 4.1 +/- 4.2. A least-squares line was computed for each patient to fit the day and counts; the slopes were significantly different from zero and negative in 7.8% of patients and positive in 14.5%. This multicenter study confirms the reports that the incidence of heparin-related severe thrombocytopenia and arterial thrombosis is distinctly low in patients treated with porcine-mucosal heparin.

Author List

Rao AK, White GC, Sherman L, Colman R, Lan G, Ball AP

Author

Gilbert C. White MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Animals
Female
Follow-Up Studies
Heparin
Humans
Injections, Intravenous
Injections, Subcutaneous
Male
Middle Aged
Multicenter Studies as Topic
Platelet Count
Prospective Studies
Swine
Thrombocytopenia