Faculty Collaboration Database

The effect of the 21-aminosteroid U74006F in a rabbit model of thromboembolic stroke. Neurosurgery 1992 Nov;31(5):929-33; discussion 933-4

Date

11/01/1992

Pubmed ID

1436419

DOI

10.1227/00006123-199211000-00016

Scopus ID

2-s2.0-0026451195 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

U74006F, a novel 21-aminosteroid, is an inhibitor of iron-dependent lipid peroxidation that is devoid of glucocorticoid and mineralocorticoid side effects. The efficacy of U74006F in reducing cerebral infarct size was investigated in a rabbit model of thromboembolic stroke. Each animal received either U74006F (3.0 mg/kg immediately before and 2 hr after embolization, n = 8) or vehicle control (n = 10). Hematocrit, mean arterial pressure, PCO2, PO2, and pH were measured and controlled both before and after the administration of an autologous clot into one internal carotid artery. Regional cerebral blood flow (in ml/100 g/min, mean +/- SEM) measured by hydrogen clearance was similar in both groups, being reduced from 68.2 +/- 9.6 to 5.2 +/- 1.9 in the control group immediately after clot embolization and from 73.3 +/- 14.9 to 7.0 +/- 1.7 in the U74006F group. Four hours after embolization the brain was harvested and cerebral infarct size was determined using the triphenyl-tetrazolium chloride technique (% hemisphere, mean +/- SEM). In the U74006F-treated group, the infarct size was significantly reduced (P < 0.05) to 14.8 +/- 6.4 from a control value of 36.0 +/- 6.4. Additionally, cerebral blood flow values after embolization were consistently higher in the U74006F group, although the differences were not statistically significant. This data suggests that the 21-aminosteroid U74006F may have a protective effect in cerebral ischemia.

Author List

Wilson JT, Bednar MM, McAuliffe TL, Raymond S, Gross CE

Author

Timothy L. McAuliffe PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Blood Flow Velocity
Brain
Cerebral Infarction
Female
Intracranial Embolism and Thrombosis
Lipid Peroxidation
Lipid Peroxides
Male
Pregnatrienes
Rabbits
Regional Blood Flow