Faculty Collaboration Database

Prolonged neonatal alloimmune thrombocytopenic purpura associated with anti-Bak(a). Two cases in siblings. Am J Perinatol 1987 Jan;4(1):55-8

Date

01/01/1987

Pubmed ID

3790217

DOI

10.1055/s-2007-999737

Scopus ID

2-s2.0-0023125406 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

Two cases of prolonged neonatal alloimmune thrombocytopenic purpura in siblings due to anti-Bak(a) are reported. The first case was complicated by an intracranial hemorrhage due to severe thrombocytopenia, but the second case had no untoward complications. Delivery by cesarean section and immediate platelet support from "compatible" (nonmaternal) donors may have contributed to the more favorable outcome in the second case. An analysis of the gene frequencies of platelet-specific antigens suggests that factors other than the potential for maternal exposure to antigen determine the incidence of affected births. Knowledge of gene frequencies may, however, permit a priori prenatal calculation of the probability of an affected birth for couples with a previously affected child even if the genotype of the father is unknown.

Author List

Miller DT, Etzel RA, McFarland JG, Aster RH, White GC 2nd

Author

Gilbert C. White MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acute Disease
Adult
Antigens, Human Platelet
Blood Platelets
Cerebral Hemorrhage
Female
Genotype
Humans
Infant, Newborn
Isoantibodies
Isoantigens
Male
Platelet Transfusion
Purpura, Thrombocytopenic
Time Factors