Faculty Collaboration Database

Wound infection rates after invasive procedures in HIV-1 seropositive versus HIV-1 seronegative hemophiliacs. Ann Surg 1990 Apr;211(4):492-8

Date

04/01/1990

Pubmed ID

2322041

Pubmed Central ID

PMC1358038

DOI

10.1097/00000658-199004000-00018

Scopus ID

2-s2.0-0025236934 (requires institutional sign-in at Scopus site)   37 Citations

Abstract

One-hundred and two patients with hemophilia A, hemophilia B, or acquired antibody to factor VIII who had undergone invasive procedures were cross referenced with patients participating in an ongoing prospective natural history study of HIV-1 infection in hemophiliacs. Matching revealed that HIV-1 status was known for 83 patients (83%) who had undergone 169 procedures between July 1979 and April 1988. Invasive procedures were classified as clean in 108 patients (63.9%), clean-contaminated in 45 (26.6%), contaminated in 2 (1.2%), and infected in 14 (8.3%). Wound infection rates by HIV-1 status were as follows (95% confidence intervals): HIV+ 1.4% (0% to 5%), HIV- 0% (0% to 9%), and procedure before testing HIV+ 1.5% (0% to 6%). There were no significant differences between the wound infection rates of HIV-positive and HIV-negative hemophiliacs nor in the wound infection rate among all three subgroups of patients (p greater than 0.5, Fisher's Exact Test). We conclude that surgery in HIV-1-infected patients who have not progressed to AIDS does not entail an increased risk of postoperative wound infections.

Author List

Buehrer JL, Weber DJ, Meyer AA, Becherer PR, Rutala WA, Wilson B, Smiley ML, White GC 2nd

Author

Gilbert C. White MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

HIV Seropositivity
Hemophilia A
Hemophilia B
Humans
Male
Risk Factors
Surgical Procedures, Operative
Surgical Wound Infection