Faculty Collaboration Database

A rabbit model of lower eyelid fibrosis. Ophthalmic Plast Reconstr Surg 2010;26(4):229-32

Date

05/27/2010

Pubmed ID

20502369

DOI

10.1097/IOP.0b013e3181b8efac

Scopus ID

2-s2.0-77955013766 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

PURPOSE: To create and validate a new model of lower eyelid fibrosis in Dutch-belted rabbits.

METHODS: Five Dutch-belted rabbits were injected with a transcutaneous 1-ml injection of standard 95% ethanol alcohol just inferior to the eyelid margin of one lower eyelid. A control injection of 1 ml of balanced saline solution was given to the opposite eyelid. A small tattoo was placed on the skin overlying the inferior orbital rim and used as a measuring point of reference in relation to the lower eyelid margin. Analysis was twofold: eyelid measurements were made over 8 weeks to determine the presence of eyelid shortening, and a histopathologic analysis was performed.

RESULTS: Mean lower eyelid shortening was greater in the ethanol alcohol intervention eyelids than the control group (-3.4 mm +/- 1.67 mm vs. 0.5 mm +/- 0.71 mm, p = 0.01). Histopathologic analysis revealed extensive fibrosis in the ethanol alcohol invention eyelids compared with the control group.

CONCLUSIONS: Ethanol alcohol induces eyelid fibrosis and lower eyelid shortening. This may be a useful model in the future testing of novel surgical or pharmacologic treatments.

Author List

Griepentrog GJ, Park DJ, Zaldivar RA, Pulido JS, Cameron JD, Woog JJ

Author

Gregory J. Griepentrog MD Associate Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Disease Models, Animal
Ethanol
Eyelids
Fibrosis
Male
Rabbits