Biological chemistry and clinical potential of S-nitrosothiols. Free Radic Biol Med 2000 May 15;28(10):1478-86
Date
08/06/2000Pubmed ID
10927172DOI
10.1016/s0891-5849(00)00248-3Scopus ID
2-s2.0-0034656848 (requires institutional sign-in at Scopus site) 252 CitationsAbstract
S-Nitrosothiols are endogenous metabolites of nitric oxide that have been detected in extra- and intracellular spaces. Many biological functions of S-nitrosothiols have been described that can be categorized as being due to one or more of the following: (i) nitric oxide release, (ii) transnitrosation, (iii) S-thiolation, and (iv) direct action. This emphasizes the fact that S-nitrosothiols are more than simply nitric oxide donors. Many of the biological functions that have been described for S-nitrosothiols have clinical correlates. This review describes the biological chemistry, biological actions, and clinical potential of these compounds.
Author List
Hogg NAuthor
Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDrug Stability
Glutathione
Humans
Mercaptoethanol
Nitric Oxide Donors
Nitroso Compounds
Penicillamine
Platelet Aggregation Inhibitors
S-Nitrosoglutathione
S-Nitrosothiols
