Polypeptide growth factors and the kidney: a developmental perspective. Pediatr Nephrol 1990 Jul;4(4):345-53
Date
07/01/1990Pubmed ID
2206902DOI
10.1007/BF00862516Scopus ID
2-s2.0-0025166799 (requires institutional sign-in at Scopus site) 37 CitationsAbstract
A variety of polypeptides with stimulatory or inhibitory effects on cell proliferation have been identified. In addition to stimulating or inhibiting the proliferation of cells and maintaining their viability, polypeptide growth factors play significant roles in embryogenesis and differentiation. The current review focuses on five specific polypeptide growth factor families (epidermal growth factor, insulin-like growth factors, transforming growth factors, platelet-derived growth factor, and fibroblast growth factors) and discusses their possible relationship to normal renal physiology, abnormal renal pathophysiology, and renal organogenesis. On the basis of current data, it is clear that polypeptide growth factors are multifunctional agents with important effects on renal function and renal organogenesis.
Author List
Avner EDAuthor
Ellis D. Avner MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Growth SubstancesHumans
Kidney
Peptides
