Angiogenesis in a patient with ischemic limb induced by intramuscular injection of vascular endothelial growth factor and fibrin platform. Tex Heart Inst J 2000;27(2):196-200
Date
08/06/2000Pubmed ID
10928508Pubmed Central ID
PMC101055Scopus ID
2-s2.0-0033942130 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
Direct revascularization of critical ischemia of the limb is often unsuccessful due to the anatomic extent and distribution of arterial occlusive disease, and no pharmacologic treatment has proved effective in treating this condition. Patients with ischemic limb may eventually require amputation and may develop serious morbidity and mortality. The goal of limb salvage in these patients has stimulated research into alternative treatment methods, including angiogenesis. Attempts have been made to apply growth factors directly or to encode DNA for such factors, but it is unknown whether these factors remain at the target site long enough to be effective. We report our strategy of using vascular endothelial growth factor in a fibrin network, which enables the sustained release of biologic material at the target site.
Author List
Kipshidze N, Chekanov V, Chawla P, Shankar LR, Gosset JB, Kumar K, Hammen D, Gordon J, Keelan MHAuthor
James B. Gosset MD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedEndothelial Growth Factors
Fibrin Tissue Adhesive
Humans
Injections, Intramuscular
Ischemia
Leg
Lymphokines
Male
Neovascularization, Physiologic
Protein Isoforms
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
