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Total and active ghrelin in developing rats during hypoxia. Endocrine 2003 Jul;21(2):159-61

Date

08/05/2003

Pubmed ID

12897380

DOI

10.1385/ENDO:21:2:159

Scopus ID

2-s2.0-0042205288   23 Citations

Abstract

Hypoxia is well known to decrease appetite and weight gain in growing rats, and to induce weight loss in humans. It has been hypothesized that this is mediated by a change in ghrelin, an orexigenic peptide synthesized and released primarily from the stomach. Rats were exposed to hypoxia for 7 d as neonates (birth-7 d of age), weanlings (28-35 d of age), and juveniles (49-56 d of age). Hypoxia had no effect on total or active plasma ghrelin. There was a significant decrease in active ghrelin in weaned rats (0.8 +/- 0.1 ng/mL) compared to nursing pups at 7 d of age (2.3 +/- 0.2 ng/mL). The proportion of total ghrelin that was active decreased significantly between 7 and 35 d of age. We conclude that the anorexia and weight loss associated with hypoxia is probably not mediated by ghrelin. There appear to be changes in active ghrelin levels in plasma during early development in the rat.

Author List

Raff H

Author

Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aging
Animals
Animals, Newborn
Animals, Suckling
Body Weight
Eating
Female
Ghrelin
Hypoxia
Peptide Hormones
Peptides
Rats
Rats, Sprague-Dawley
Weight Loss
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d