Faculty Collaboration Database

Simultaneous ERP and fMRI of the auditory cortex in a passive oddball paradigm. Neuroimage 2003 Aug;19(4):1395-404

Date

09/02/2003

Pubmed ID

12948697

DOI

10.1016/s1053-8119(03)00228-3

Scopus ID

2-s2.0-0041924827 (requires institutional sign-in at Scopus site)   144 Citations

Abstract

Infrequent occurrences of a deviant sound within a sequence of repetitive standard sounds elicit the automatic mismatch negativity (MMN) event-related potential (ERP). The main MMN generators are located in the superior temporal cortex, but their number, precise location, and temporal sequence of activation remain unclear. In this study, ERP and functional magnetic resonance imaging (fMRI) data were obtained simultaneously during a passive frequency oddball paradigm. There were three conditions, a STANDARD, a SMALL deviant, and a LARGE deviant. A clustered image acquisition technique was applied to prevent contamination of the fMRI data by the acoustic noise of the scanner and to limit contamination of the electroencephalogram (EEG) by the gradient-switching artifact. The ERP data were used to identify areas in which the blood oxygenation (BOLD) signal varied with the magnitude of the negativity in each condition. A significant ERP MMN was obtained, with larger peaks to LARGE deviants and with frontocentral scalp distribution, consistent with the MMN reported outside the magnetic field. This result validates the experimental procedures for simultaneous ERP/fMRI of the auditory cortex. Main foci of increased BOLD signal were observed in the right superior temporal gyrus [STG; Brodmann area (BA) 22] and right superior temporal plane (STP; BA 41 and 42). The imaging results provide new information supporting the idea that generators in the right lateral aspect of the STG are implicated in processes of frequency deviant detection, in addition to generators in the right and left STP.

Author List

Liebenthal E, Ellingson ML, Spanaki MV, Prieto TE, Ropella KM, Binder JR

Author

Jeffrey R. Binder MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Arousal
Attention
Auditory Cortex
Brain Mapping
Contingent Negative Variation
Electroencephalography
Evoked Potentials, Auditory
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
Oxygen Consumption
Pitch Discrimination
Temporal Lobe