Beta tryptase levels are not elevated in patients undergoing liver transplantation. Liver Transpl 2003 Sep;9(9):980-2
Date
08/28/2003Pubmed ID
12942461DOI
10.1053/jlts.2003.50160Scopus ID
2-s2.0-0042381384 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Reperfusion syndrome during liver transplantation and anaphylaxis are clinical syndromes that share similarities in physiological responses. The liver and intestine contain a variety of immunologically active cells, including mast cells. The purpose of this study is to investigate the possibility that mast-cell degranulation occurs routinely during transplantation and thereby contributes to hemodynamic instability and coagulopathy. Beta tryptase, an enzyme released by mast cells during degranulation, is a reliable marker for mast-cell-mediated events. Six patients undergoing liver transplantation had beta tryptase levels assayed in blood immediately before and after reperfusion of the liver. No patient showed an increase in beta tryptase levels at 15 or 60 minutes after reperfusion. In conclusion, it is unlikely that clinically significant mast-cell degranulation occurs routinely in patients undergoing liver transplantation.
Author List
Woehlck HJ, Johnson CP, Roza AM, Adams MBAuthors
Christopher P. Johnson MD Professor in the Surgery department at Medical College of WisconsinHarvey J. Woehlck MD Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnaphylaxisCell Degranulation
Humans
Liver Transplantation
Mast Cells
Reperfusion Injury
Serine Endopeptidases
Tryptases
