Evaluation of end points of serial drug testing in patients with sustained ventricular tachycardia after healing of acute myocardial infarction. Am J Cardiol 1995 Dec 15;76(17):1247-52
Date
12/15/1995Pubmed ID
7503005DOI
10.1016/s0002-9149(99)80351-8Scopus ID
2-s2.0-0028806165 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Serial electrophysiologic drug testing was used to guide antiarrhythmic therapy in a consecutive series of 150 patients with clinical sustained ventricular tachycardia (VT) or cardiac arrest and inducible monomorphic VT. All patients had coronary artery disease and a history of myocardial infarction. For patients with clinical sustained VT, drug responders and partial drug responders (VT slowed by drug to rate < 150 beats/min, with systolic blood pressure > or = 90 mm Hg) had similar total mortality rates (2-year actuarial survival 100% and 94%, p = NS), which were statistically different from that of patients with drug inefficacy (2-year survival 67%). Partial drug responders had high arrhythmia recurrence rates, similar to those of patients with drug inefficacy. For cardiac arrest survivors, the results of electrophysiologically guided drug testing did not predict prognosis. Patients with a change in mode of VT induction during antiarrhythmic therapy had a favorable prognosis (no deaths during follow-up).
Author List
Wasilewski SJ, Ferrick KJ, Roth JA, Kim SG, Fisher JDAuthor
James A. Roth MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Anti-Arrhythmia Agents
Evaluation Studies as Topic
Female
Heart Arrest
Humans
Male
Middle Aged
Myocardial Infarction
Prognosis
Survival Analysis
Tachycardia, Ventricular
Treatment Outcome
